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. Author manuscript; available in PMC: 2021 Sep 15.
Published in final edited form as: J Immunol. 2020 Aug 19;205(6):1664–1677. doi: 10.4049/jimmunol.2000247

Figure 8.

Figure 8.

IL10 stimulation shifted BMDMs to an M2-biased phenotype in vitro. A: QPCR data showed induction of Il10 gene expression in WT muscle after injury. Il10 expression was ablated in non-injured and injured muscle 3-, 7- and 15-dpi from Il10−/− mice. Values were normalized to non-injured WT TA muscle. # indicates significant difference (P < 0.05) from WT at a time point. P-values based on two-tailed t-test. N = 4-5 for each data set. B: QPCR data showing that WT BMDMs stimulated with IL10 reduced iNOS and increased Ifng, Arg1, Arg2 and Mrc1 expression. All values were normalized to non-stimulated (CON) WT BMDMs and set at 1. # indicates significant difference (P < 0.05) from CON BMDMs. P-values based on two-tailed t-test. N = 3-4 for each data set. Data are presented as mean ± SEM.