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. 2020 Feb 25;26(10):5940–5954. doi: 10.1038/s41380-020-0674-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a–e increased and somatodendritic redistribution of p-tau in the anterior cingulate cortex and motor cortex of blast-exposed rats 6 weeks following blast exposure. Shown are sections of the anterior cingulate a–e of control a, c and blast-exposed rats b, d, e immunostained with AT270 (green) counterstained with DAPI (blue). Cortical layers are indicated in panel c. Note the general increase of p-tau in all cortical layers in the blast-exposed animals b, d. e Higher power image of the neuron outlined by the white box in panel d showing prominent somatodendritic localization of p-tau. f–k perivascular p-tau in astroglial processes 10 months after blast-exposure. Penetrating cortical vessels from control f–h and blast-exposed rats i–k AT270 (green, f and i) and GFAP (red, g and j). The arrow in panel i indicates p-tau staining. An arrow in panel d indicates p-tau staining that appears to be in an elastic membrane. Arrowheads in panel d indicate other examples of perivascular tau staining. A penetrating cortical vessel that was not stained is indicated by an arrowhead in panel c. Scale bar: 50 μm a, b, 25 μm c, d, 10 μm e. Scale bar for panels f–k: 20 μm.