Table 2a.
Summary of top 20 most significant differentially expressed genes, based on alcohol use disorder, adjusted for current smoking as a categorical variable (yes/no). The full gene list may be found in Supplemental Table 1.
| ProbeName | Symbol | EntrezID | Log fold- change |
Average expression |
t | p value | Adjusted p value |
|---|---|---|---|---|---|---|---|
| A_23_P101351 | ZNF426* | 79088 | −1.6139492 | 5.345018 | −6.021046 | 8.00e-07 | 0.0091115 |
| A_33_P3348887 | PBX3* | 5090 | 2.2587736 | 3.696095 | 5.877560 | 1.20e-06 | 0.0091115 |
| A_33_P3353552 | SLC48A1 | 55652 | −0.8148278 | 7.009872 | −5.755836 | 1.80e-06 | 0.0091115 |
| A_23_P120710 | TTC3# | 7267 | −0.6627020 | 7.820126 | −5.645005 | 2.50e-06 | 0.0095240 |
| A_23_P419624 | BLCAP*# | 10904 | −0.7082976 | 8.201873 | −5.496883 | 3.90e-06 | 0.0115758 |
| A_23_P129221 | FAH | 2184 | −1.6225324 | 4.880897 | −5.444574 | 4.50e-06 | 0.0115758 |
| A_23_P217666 | RPL10*# | 6134 | −0.4143518 | 14.179896 | −5.352965 | 6.00e-06 | 0.0130555 |
| A_33_P3219803 | PTMA*# | 5757 | 1.0305163 | 13.786352 | 5.306091 | 6.90e-06 | 0.0131453 |
| A_23_P102404 | CCT7*# | 10574 | −0.4937125 | 10.698977 | −5.209633 | 9.20e-06 | 0.0155959 |
| A_23_P77415 | OSGIN1 | 29948 | −2.6576696 | 3.763180 | −5.110453 | 1.24e-05 | 0.0168854 |
| A_23_P66719 | DHRS13*# | 147015 | −1.6403834 | 4.935906 | −5.098374 | 1.28e-05 | 0.0168854 |
| A_23_P102404 | CCT7*# | 10574 | −0.5118417 | 10.945969 | −5.086847 | 1.33e-05 | 0.0168854 |
| A_23_P309803 | ZNF777 | 27153 | 0.4841887 | 7.937413 | 5.027023 | 1.59e-05 | 0.0186353 |
| A_32_P225604 | RPL5*# | 6125 | −0.4978655 | 13.559090 | −4.936844 | 2.07e-05 | 0.0222872 |
| A_24_P844984 | PIGR | 5284 | 0.6227903 | 13.951730 | 4.907237 | 2.27e-05 | 0.0222872 |
| A_23_P122007 | C5orf30 | 90355 | −1.2693265 | 6.869129 | −4.875647 | 2.49e-05 | 0.0222872 |
| A_23_P115215 | VPS72 | 6944 | −0.4665451 | 7.830694 | −4.852218 | 2.67e-05 | 0.0222872 |
| A_33_P3213419 | LOC100129447 | 100129447 | 1.9628734 | 5.617893 | 4.844685 | 2.73e-05 | 0.0222872 |
| A_23_P105571 | CHPT1 | 56994 | −1.7743049 | 3.603385 | −4.815341 | 2.98e-05 | 0.0222872 |
| A_23_P123330 | RPL30*# | 6156 | −0.4240935 | 13.358958 | −4.812120 | 3.01e-05 | 0.0222872 |
*
denotes genes that were also differentially expressed in model adjusting for pack-years smoking as a continuous variable (as described in figure 2b).
#
denotes genes that were also differentially expressed in model that included control (n=11) and AUD (n=11) participants with <10 pack-year smoking history.