Table 2b.
Summary of top 20 most significant differentially expressed genes, based on AUD, adjusted for pack-years smoking as a continuous variable. The full gene list may be found in Supplemental Table 2.
| ProbeName | Symbol | EntrezID | Log fold- change |
Average expression |
t | p value | Adjusted p value |
|---|---|---|---|---|---|---|---|
| A_32_P225604 | RPL5*# | 6125 | −0.6207947 | 13.559090 | −6.684604 | 1.0e-07 | 0.0011786 |
| A_23_P123330 | RPL30*# | 6156 | −0.5323540 | 13.358958 | −6.498355 | 2.0e-07 | 0.0011786 |
| A_23_P101351 | ZNF426* | 79088 | −1.5577416 | 5.345018 | −6.338923 | 3.0e-07 | 0.0011786 |
| A_32_P104432 | SMIM10L2B | 644596 | −1.6107530 | 3.660787 | −6.249990 | 4.0e-07 | 0.0011786 |
| A_23_P217666 | RPL10*# | 6134 | −0.4405652 | 14.179896 | −6.242387 | 4.0e-07 | 0.0011786 |
| A_23_P102404 | CCT7* | 10574 | −0.5501780 | 10.698977 | −6.184088 | 5.0e-07 | 0.0011786 |
| A_33_P3219803 | PTMA*# | 5757 | 1.1026929 | 13.786352 | 6.156888 | 5.0e-07 | 0.0011786 |
| A_23_P123330 | RPL30*# | 6156 | −0.5010585 | 13.564073 | −6.055543 | 7.0e-07 | 0.0012622 |
| A_23_P102404 | CCT7*# | 10574 | −0.5667809 | 10.945969 | −6.049635 | 7.0e-07 | 0.0012622 |
| A_23_P66719 | DHRS13*# | 147015 | −1.7148302 | 4.935906 | −5.880515 | 1.2e-06 | 0.0015521 |
| A_23_P419624 | BLCAP*# | 10904 | −0.6874833 | 8.201873 | −5.878118 | 1.2e-06 | 0.0015521 |
| A_23_P123330 | RPL30*# | 6156 | −0.4944068 | 13.412823 | −5.871070 | 1.3e-06 | 0.0015521 |
| A_23_P123330 | RPL30*# | 6156 | −0.4932770 | 13.263023 | −5.857418 | 1.3e-06 | 0.0015521 |
| A_23_P125519 | RPS4X | 6191 | −0.4533311 | 13.686688 | −5.830215 | 1.4e-06 | 0.0015634 |
| A_23_P123330 | RPL30*# | 6156 | −0.4787982 | 13.288719 | −5.802078 | 1.6e-06 | 0.0015874 |
| A_23_P258002 | CDKN2AIP | 55602 | −1.4786530 | 4.875930 | −5.721616 | 2.0e-06 | 0.0018936 |
| A_23_P123330 | RPL30*# | 6156 | −0.4733975 | 13.372103 | −5.691457 | 2.2e-06 | 0.0019506 |
| A_33_P3348887 | PBX3* | 5090 | 1.7849662 | 3.696095 | 5.633107 | 2.6e-06 | 0.0021941 |
| A_33_P3241582 | RPS15A | 6210 | −0.4600710 | 13.536785 | −5.593442 | 2.9e-06 | 0.0023410 |
| A_23_P102404 | CCT7*# | 10574 | −0.5674271 | 10.999433 | −5.560850 | 3.2e-06 | 0.0023510 |
*
denotes genes that were also differentially expressed in model adjusting for current smoking as a categorical variable (as described in figure 2a).
#
denotes genes that were also differentially expressed in model that included control (n=11) and AUD (n=11) participants with <10 pack-year smoking history.