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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Gastroenterology. 2020 Apr 20;159(2):575–590. doi: 10.1053/j.gastro.2020.04.033

Figure 3.

Figure 3.

Overexpression of NOTCH2 in Lgr5+ progenitor cells accelerates the development of metaplasia, dysplasia, and esophageal tumors in L2-IL1B mice. (A) (upper panel) Macroscopic images of the distal esophagus and gastric cardia, sliced along the sagittal plane, and (lower panel) representative H&E staining of pL2.Lgr5 control mice, pL2.Lgr5N2fl/fl, pL2.Lgr5.N2IC mice at indicated time points. Statistical analysis of the (B) macroscopic tumor score, and histopathological scoring for (C) metaplasia, and (D) dysplasia. Data is presented as means ± standard deviation. Statistical analysis were performed using one-way ANOVA and Tukeys multiple comparison test.*p<.05.