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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Gastroenterology. 2020 Apr 20;159(2):575–590. doi: 10.1053/j.gastro.2020.04.033

Figure 4.

Figure 4.

Notch2 overexpression in Lgr5+ cells leads to increased crypt fission and impedes the differentiation of mucus producing cells. (A) Representative images for goblet-like cell maturation and crypt fission. (B) Statistical summary of PAS staining indicating goblet-like cell maturation and (C) goblet-like cells frequencies indicated as GC ratio. (D) Linear regression of pathological progression correlating the macroscopic and dysplasia score with GC ratio. (E) Cell proliferation was evaluated by Ki67 reactivity and (F) crypt fission events. Analysis was performed in the BE region in 10 high-power fields. Data is presented as means ± standard deviation. Statistical analysis were performed using one-way ANOVA and Tukey’s multiple comparison test. *p<.05.