Table 5.

Comparison of latent profiles considering known risk factors.

Risk Factor	Primarily Alcohol	Primarily Heroin	Less PSU	Tranquilizer PSU	Primarily Buprenorphine	Stimulant-Opioid
Comorbid mental health concerns				X	X	X
HCV positive		X				X
Heavy co-use of substances known to contribute to overdose	X			X		X
Homeless		X				X
History of injection drug use		X		X	X	X
Resource limited (high economic hardship and/or rurally located)		X		X	X	X
Concerns of tolerance (extensive criminal histories)	X					X

Note: PSU = polysubstance use. Categorizations made based on bivariate and multinomial logistic regression results. Results indicate other profiles are more at risk than the Less PSU profile, but this profile still represents a vulnerable population and risk is ever-present.