Figure 6. The IDE inhibitor prevents the degradation of the microinjected synthetic and physiological sAβ in vivo.

(A and B) Two hours or five days after surgery, mouse brains were removed and homogenized. The Aβ₄₂ level in the homogenates was measured by ELISA as described in the Methods. The data represent the means ± SEM of all mice in each group (n = 5 females per group); ** p < 0.01 versus the group of FLsAβ₄₂ 2 h (A) or the group of AD-TBS 2 h (B); ## p < 0.01 versus the group of FLsAβ₄₂ 5 d (A) or the group of AD-TBS 5 d (B) (nonparametric Mann Whitney test). Detailed statistical results are shown in Table 2.