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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Circulation. 2020 Jul 9;142(9):882–898. doi: 10.1161/CIRCULATIONAHA.120.046356

Figure 4. FoxO1 is increased at the TSS in all subsets of genes regulated by pol II during cardiac hypertrophy.

Figure 4.

A-H Forkhead box protein (Fox)O1 and RNA polymerase (pol)II ChIP-Seq were performed in Sham and transverse aortic constriction (TAC) hearts as described in Figure 1. Average peak values for all merged regions of expressed genes (pol II sequencing tags > 35 in Sham or TAC at the transcription start site (TSS)) containing FoxO1 (FoxO1 sequencing tags > 35 in Sham or TAC at the TSS) were plotted for pol II (left panels) at the TSS or in-gene (IG) regions, or FoxO1 (right panels) at the TSS during Sham or TAC. The data are represented as violin plots showing the median, quartiles, and distribution (A, C, E, and G) or as bar graphs representing the mean (B, D, F, and H). Groups were defined as indicated. Error bars represent SEM. *p<0.05 TAC versus Sham using t-test.