Table 2. Pol II-regulated gene subsets during cardiac hypertrophy.

Gene subsets representing pol II de novo recruitment (TAC/Sham- pol II > 1 (TSS, in-gene)), loss (TAC/Sham- pol II < 1 (TSS, in-gene)), pause-release (TAC/Sham- pol II < 1 (TSS) and ≥ 1 (in-gene)), and pause-release + de novo recruitment (TAC/Sham- pol II < 1 (TSS) and > 1 (in-gene)) are reported as numbers of genes per group (# of genes/group) or a percentage (% of total) of the overall expressed genes (pol II tags > 35 at TSS in Sham or TAC) (11213 genes). The number of genes that bind forkhead box protein (Fox)O1 (FoxO1 tags > 35 at TSS in Sham or TAC) for each group is also reported (# of genes/group (FoxO1 binding)) and displayed as percentages (%). 35 was selected as a stringent cutoff as input DNA tags averaged 31 and 9 at the TSS in the pol II and FoxO1 ChIP-Seq datasets, respectively. Of these FoxO1-bound genes, the number of genes per group with increased (TAC/Sham- FoxO1 > 1) or decreased (TAC/Sham- FoxO1 < 1) FoxO1 binding following TAC (# of genes/group (FoxO1 increased) or # of genes/group (FoxO1 decreased), respectively) was also reported and displayed with their respective percentages (%).

	# of genes/group	% of Total (11213 genes)	# of genes/group (FoxO1 binding)	%	# of genes/group (FoxO1 increased)	%	# of genes/group (FoxO1 decreased)	%
De novo Recruitment	666	5.94	528	79.28	521	78.23	75	11.26
Loss	249	2.22	179	71.89	173	69.48	6	2.41
Pause-Release	6252	55.76	5971	95.51	5849	93.55	119	1.90
Pause-Release + De novo Recruitment	2639	23.54	2530	95.87	2487	94.24	41	1.55