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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: J Immunol. 2020 Aug 3;205(5):1331–1344. doi: 10.4049/jimmunol.1901431

Fig. 6. IL-15 responding cells increase consistent with control of viral rebound by CD8 Ab administration.

Fig. 6

To examine levels of IL-15 responding cells, PBMC samples collected from the CD8 Ab treated animals were subjected to the ex-vivo assay described.

Left panels: Relation between the kinetics of depletion of CD8+ T cells (closed circle) and NK cells (open circle) and viral rebound (open triangle) in 5 controller animals (Mm0517, Mm0512, Mm0511, Mm0303 and Mm0516).

Right panels: Frequencies of CD107a+CD8+ T cells (gray) and CD107a+NK (white) cells in PBMCs from the same 5 controller monkeys obtained at various times post depletion of CD8- expressing cells using the CD8 Ab.