Table 3.
Adjusted1 hazard ratios (HRs) and 95% confidence intervals (CIs) for associations of saturated fatty acid intake with risk of pancreatic cancer overall and among women aged ≥50 years.
| All Ages |
Age ≥ 50 years |
|||||||
|---|---|---|---|---|---|---|---|---|
| Intake (g/day) | N Cases | Person- years |
HR | (95% CI) | N Cases | Person- years |
HR | (95% CI) |
| Total Saturated Fat | ||||||||
| Quartile 1 | 39 | 253,786 | 1.00 | – | 33 | 133,634 | 1.00 | – |
| Quartile 2 | 39 | 254,511 | 1.07 | (0.67, 1.69) | 36 | 125,652 | 1.22 | (0.74, 1.99) |
| Quartile 3 | 42 | 253,859 | 1.23 | (0.75, 2.04) | 39 | 115,595 | 1.49 | (0.87, 2.54) |
| Quartile 4 | 48 | 253,489 | 1.56 | (0.82, 2.99) | 40 | 101,650 | 1.85 | (0.92, 3.72) |
| Ptrend2 | 0.2 | 0.08 | ||||||
| Continuous (per 10 g/day) | 0.93 | (0.69, 1.25) | 1.04 | (0.76, 1.42) | ||||
| Fatty Acid 4:0 (Butyric Acid) | ||||||||
| Quartile 1 | 42 | 247,181 | 1.00 | – | 37 | 137,178 | 1.00 | – |
| Quartile 2 | 34 | 254,551 | 0.91 | (0.57, 1.44) | 31 | 122,764 | 0.97 | (0.60, 1.58) |
| Quartile 3 | 51 | 256,278 | 1.39 | (0.90, 2.15) | 48 | 114,813 | 1.57 | (1.00, 2.47) |
| Quartile 4 | 40 | 250,292 | 1.13 | (0.68, 1.89) | 31 | 99,485 | 1.09 | (0.63, 1.90) |
| Ptrend2 | 0.4 | 0.6 | ||||||
| Continuous (per 1 g/day) | 1.21 | (0.52, 2.81) | 1.24 | (0.50, 3.07) | ||||
| Fatty Acid 6:0 (Caproic Acid) | ||||||||
| Quartile 1 | 37 | 246,535 | 1.00 | – | 33 | 133,757 | 1.00 | – |
| Quartile 2 | 43 | 256,730 | 1.27 | (0.81, 1.98) | 38 | 124,606 | 1.30 | (0.81, 2.08) |
| Quartile 3 | 42 | 253,682 | 1.30 | (0.82, 2.07) | 38 | 113,100 | 1.41 | (0.87, 2.29) |
| Quartile 4 | 45 | 249,610 | 1.40 | (0.85, 2.31) | 38 | 101,951 | 1.46 | (0.85, 2.49) |
| Ptrend2 | 0.3 | 0.2 | ||||||
| Continuous (per 1 g/day) | 1.66 | (0.36, 7.64) | 2.10 | (0.41, 10.69) | ||||
| Fatty Acid 8:0 (Caprylic Acid) | ||||||||
| Quartile 1 | 46 | 262,815 | 1.00 | – | 41 | 143,567 | 1.00 | – |
| Quartile 2 | 31 | 236,417 | 0.88 | (0.56, 1.40) | 27 | 110,470 | 0.90 | (0.55, 1.47) |
| Quartile 3 | 47 | 260,409 | 1.18 | (0.77, 1.81) | 45 | 119,214 | 1.32 | (0.84, 2.06) |
| Quartile 4 | 44 | 250,820 | 1.13 | (0.69, 1.86) | 35 | 101,567 | 1.09 | (0.64, 1.87) |
| Ptrend2 | 0.5 | 0.6 | ||||||
| Continuous (per 1 g/day) | 1.50 | (0.16, 14.11) | 1.80 | (0.16, 19.90) | ||||
| Fatty Acid 10:0 (Capric Acid) | ||||||||
| Quartile 1 | 44 | 250,201 | 1.00 | – | 38 | 136,345 | 1.00 | – |
| Quartile 2 | 33 | 251,086 | 0.86 | (0.54, 1.35) | 31 | 120,626 | 0.97 | (0.60, 1.57) |
| Quartile 3 | 50 | 257,858 | 1.25 | (0.81, 1.92) | 46 | 116,336 | 1.41 | (0.89, 2.23) |
| Quartile 4 | 40 | 250,508 | 1.00 | (0.59, 1.67) | 32 | 101,133 | 1.02 | (0.58, 1.79) |
| Ptrend2 | 0.8 | 0.8 | ||||||
| Continuous (per 1 g/day) | 1.18 | (0.40, 3.49) | 1.35 | (0.42, 4.28) | ||||
| Fatty Acid 12:0 (Lauric Acid) | ||||||||
| Quartile 1 | 38 | 252,089 | 1.00 | – | 34 | 138,978 | 1.00 | – |
| Quartile 2 | 43 | 249,861 | 1.34 | (0.86, 2.08) | 37 | 119,700 | 1.33 | (0.83, 2.15) |
| Quartile 3 | 44 | 258,676 | 1.33 | (0.84, 2.13) | 43 | 115,631 | 1.55 | (0.96, 2.51) |
| Quartile 4 | 43 | 249,811 | 1.34 | (0.78, 2.29) | 34 | 100,311 | 1.30 | (0.73, 2.33) |
| Ptrend2 | 0.4 | 0.5 | ||||||
| Continuous (per 1 g/day) | 0.88 | (0.44, 1.77) | 0.96 | (0.46, 2.03) | ||||
| Fatty Acid 14:0 (Myristic Acid) | ||||||||
| Quartile 1 | 40 | 250,653 | 1.00 | – | 34 | 137,943 | 1.00 | – |
| Quartile 2 | 41 | 253,663 | 1.15 | (0.74, 1.80) | 37 | 124,127 | 1.28 | (0.79, 2.06) |
| Quartile 3 | 41 | 254,591 | 1.19 | (0.74, 1.92) | 40 | 114,411 | 1.48 | (0.90, 2.44) |
| Quartile 4 | 46 | 252,700 | 1.43 | (0.82, 2.49) | 37 | 98,715 | 1.56 | (0.86, 2.83) |
| Ptrend2 | 0.2 | 0.2 | ||||||
| Continuous (per 1 g/day) | 1.07 | (0.83, 1.37) | 1.13 | (0.87, 1.47) | ||||
| Fatty Acid 16:0 (Palmitic Acid) | ||||||||
| Quartile 1 | 38 | 253,826 | 1.00 | – | 32 | 132,820 | 1.00 | – |
| Quartile 2 | 41 | 254,648 | 1.11 | (0.70, 1.76) | 38 | 125,199 | 1.26 | (0.77, 2.07) |
| Quartile 3 | 43 | 254,164 | 1.23 | (0.74, 2.04) | 41 | 116,351 | 1.48 | (0.86, 2.55) |
| Quartile 4 | 46 | 253,565 | 1.40 | (0.71, 2.76) | 37 | 102,327 | 1.54 | (0.74, 3.21) |
| Ptrend2 | 0.3 | 0.3 | ||||||
| Continuous (per 1 g/day) | 0.98 | (0.93, 1.04) | 1.00 | (0.94, 1.07) | ||||
| Fatty Acid 18:0 (Stearic Acid) | ||||||||
| Quartile 1 | 42 | 254,106 | 1.00 | – | 35 | 133,107 | 1.00 | – |
| Quartile 2 | 39 | 253,998 | 0.97 | (0.61, 1.52) | 37 | 124,865 | 1.15 | (0.71, 1.86) |
| Quartile 3 | 39 | 254,435 | 1.00 | (0.61, 1.66) | 36 | 115,677 | 1.22 | (0.71, 2.09) |
| Quartile 4 | 47 | 253,341 | 1.26 | (0.66, 2.42) | 39 | 102,924 | 1.52 | (0.76, 3.06) |
| Ptrend2 | 0.4 | 0.2 | ||||||
| Continuous (per 1 g/day) | 0.95 | (0.85, 1.06) | 1.00 | (0.88, 1.12) | ||||
1
Adjusted for age (continuous), cigarette smoking (never, former, current; pack-years), and total energy intake (kcals).
2
Tests for linear trend were calculated by assigning the median of each quartile as scores.