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. Author manuscript; available in PMC: 2020 Sep 11.
Published in final edited form as: Cell Rep. 2020 Jul 7;32(1):107866. doi: 10.1016/j.celrep.2020.107866

Figure 4. Neto-α Is Required for the Presynaptic Homeostatic Response.

Figure 4.

(A) Representative traces for mEJP and EJP recordings from muscle 6 of the indicated genotypes.

(B) Quantification of mEJP amplitude and QC values normalized to control (w1118).

(C) Representative traces for mEJP and EJP recordings before and after PhTx treatment in control and neto-αnull mutants.

(D) Quantification of mEJP amplitude and QC values after PhTx, normalized to the baseline values of the same genotype. Following PhTx application, neto-αnull mutants fail to restore their basal neurotransmission and show no increase in QC.

(E) Representative traces for mEJP and EJP recordings before and after PhTx application in neto-αnull mutants rescued by muscle- or neuron-expressed neto-α.

(F) Quantification of mEJP amplitude and QC relative values shows QC increase only in neuronally rescued mutants.

Data are represented as mean ± SEM.****p < 0.0001; ***p < 0.001; **p < 0.01; *p < 0.05; ns, p > 0.05.