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. 2020 Aug 28;10:1693. doi: 10.3389/fonc.2020.01693

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Copyright © 2020 Marima, Hull, Dlamini and Penny.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cell cycle distribution in response to ARV drugs. (A,B) Show bar graphs of EFV treated MRC-5 cells at 24 and 48 h. (C,D) Demonstrate bar graphs of A549 cells treated with EFV at 24 and 48 h. (E,F) Illustrate bar graphs of MRC-5 cells treated with LPV/r at 24 and 48 h, while (G,H) are bar graphs of A549 LPV/r treated cells at 24 and 48 h. The increase in S-phase, (S-phase arrest) observed here is statistically significant with p < 0.0 1. A significant increase in G2/M with p < 0.05 in A549 10 μM LPV/r treated cells is also evident. Error bars denote SEM; *p < 0.05; **p < 0.01.