Fig. 4.

Differential expression changes of metabolites after one to two fractions of SBRT from baseline by in-field tumour response at three months post SBRT. (a) Heatmap of differential upregulation or downregulation (all three p-values ≤0⋅05) of plasma metabolites in HCC patients with response (complete/partial, CR/PR, yellow) vs. those with no response (stable disease, SD, green) at three months post SBRT. Each column represents a patient. Each row represents an individual metabolite. The more intense the red colour, the higher the level of the metabolite was detected. The more intense the blue colour, the lower the level of the metabolite was detected. (b) Representative boxplots showing the fold change of 4 metabolites plotted against in-field tumour response at 3 months post SBRT.