Table 3.
Characteristics of the studies evaluated of group 2, Autologous bone graft substitute.
| Author/year [ref.] | n. |
Study type | Experimental group biomaterials | Graft type | Control group | Follow-up (months) | Radiographical assessment type | Conclusion | Bias risk | |
|---|---|---|---|---|---|---|---|---|---|---|
| Experimental group | Experimental group | |||||||||
| Neovius et al. (2013) | 4 | 3 | RCT | BMP2 in hydrogel | Synthetic | Iliac bone | 6 months postoperatively | CT san after 6 months. | BMP2 causes severe postoperative swelling. The use of hydrogel as a BMP2 delivery vehicle may reduce the amount of growth factors needed to achieve therapeutic repair. |
3- High risk |
| Pradel and Lauer (2012) | 4 | 4 | PCT | Autogenous osteoblasts cultured on the demineralized bone matrix Osteovit | Heterograft | Iliac bone | 6 months postoperatively | CT scan after 6 months | The use of autogenous osteoblasts cultured on Osteovit is a promising alternative in alveolar cleft repair. No disadvantages in comparison to traditional bone grafts were observed. | 3- High risk |
| Canan et al. (2012) | 12 | 6 | RCT | rhBMP2 in collagen sponges | Synthetic | Iliac bone | 3, 6, and 12 months postoperativel | CT scan after 3, 6 and 12 months | There was no difference among the groups analyzed. | 3- High risk |
| Alonso et al. (2010) | 8 | 8 | RCT | Resorbable collagen matrix with rhBMP2 | Synthetic | Iliac bone | 6 and 12 months postoperatively | CT scan after 6 and 12 months | The use of rhBMP2 for repairing alveolar cleft yielded satisfactory bone healing and avoided donor site morbidity. | 2- Unclear |
| Dickinson et al. (2008) | 9 | 12 | RCT | Collagen matrix/BMP2 construct | Synthetic | Iliac bone | 6 months postoperatively | CT, Panorex, periapical views after 6 months | BMP2 improved bone healing and reduced morbidity compared with traditional iliac bone grafts. | 2- Unclear |
PCT: prospective controlled trial.
RCT: randomized controlled trial.
CT: computed tomography.