TABLE 1.

Basic metabolic parameters measured in interventional study

	Chow	Chow + ibrutinib (30 mg·kg−1)	HFD + Veh	HFD + ibrutinib (3 mg·kg−1)	HFD + ibrutinib (30 mg·kg−1)
Body weight (g)	31.24 ± 0.43*	30.65 ± 0.51*	36.1 ± 0.80	33.55 ± 0.79	31.21 ± 0.31
Weight gain from baseline (g)	7.03 ± 0.54*	6.84 ± 1.85*	11.22 ± 0.51	9.42 ± 0.508	9.91 ± 0.83
Kidney weight (g)	0.3088 ± 0.007	0.3362 ± 0.002	0.3295 ± 0.011	0.3198 ± 0.010	0.3029 ± 0.007
Liver weight (g)	1.185 ± 0.038*	1.187 ± 0.065*	2.817 ± 0.048	1.256 ± 0.048*	1.287 ± 0.0442*
Inguinal fat weight (g)	0.394 ± 0.043*	0.3837 ± 0.003*	0.4531 ± 0.037	0.3505 ± 0.089*	0.3993 ± 0.028*
ALT (U·L−1)	45.40 ± 19.95	46.00 ± 11.68	61.04 ± 13.16	58.47 ± 9.031	54.63 ± 7.16
AST (U·L−1)	80.88 ± 5.887*	92.01 ± 22.67	120.4 ± 16.55	115 ± 11.87	119 ± 12.18

Body weight, body weight gain from baseline, inguinal fat weight, kidney weight, liver weight, inguinal fat weight, ALT, and AST were measured in mice fed a standard diet (chow) or a high‐fat diet (HFD) for 12 weeks. HFD mice were treated with either vehicle or ibrutinib (3 or 30 mg·kg⁻¹ p.o.) five times per weeks between weeks 7 and 12. Data are expressed as mean ± SEM from 9/10 mice per group.

^* P < 0.05, significantly different from HFD + Veh. one‐way ANOVA with Bonferroni post hoc test.