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Affinity of SNF472 to hydroxyapatite (HAP) crystals after incubation for 8 h. (a) Adsorption of HAP 25, 75, 130 or 300 mg was saturated at a SNF472 concentration of 7.6 μM. Calculated values for maximum adsorption to HAP (Bmax) were between 6 and 7 μM in all cases. (b) The calculated K D for adsorption was linear for HAP
