Table 3.

ADME Properties of selected inhibitors of Nsp9 replicase.

S. No	Compound	Molecular formula	ADME Properties (Lipinki’s Rule of Five)		Structure	Drug likeliness
			Properties	Value
1.	Conivaptan	C32H26N4O2	Molecular weight (<500Da)	498.57		Yes
			LogP (<5)	5
			H-Bond donor (5)	2
			H-bond acceptor (<10)	3
			Violations	0
2.	Telmisartan	C33H30N402	Molecular weight (<500Da)	514.62		Yes
			LogP (<5)	5.9
			H-Bond donor (5)	1
			H-bond acceptor (<10)	4
			Violations	2
3.	Phaitanthrin D	C17H12N203	Molecular weight (<500Da)	292.29		Yes
			LogP (<5)	1.7
			H-Bond donor (5)	1
			H-bond acceptor (<10)	3
			Violations	0
4.	Phytosterols	C29H50O	Molecular weight (<500Da)	414.71		Yes
			LogP (<5)	7.1
			H-Bond donor (5)	1
			H-bond acceptor (<10)	1
			Violations	1
5.	Withanolide R	C28H38O6	Molecular weight (<500Da)	454.60		Yes
			LogP (<5)	3.9
			H-Bond donor (5)	2
			H-bond acceptor (<10)	5
			Violations	0
6.	Withanolide G	C28H38O5	Molecular weight (<500Da)	480.64		Yes
			LogP (<5)	4.1
			H-Bond donor (5)	1
			H-bond acceptor (<10)	6
			Violations	0
7.	17-alpha-hydroxywithanolide D	C28H40O7	Molecular weight (<500Da)	488.61		Yes
			LogP (<5)	2.1
			H-Bond donor (5)	4
			H-bond acceptor (<10)	7
			Violations	0
8	Stigmasta-5, 22-dien-3-ol	C29H48O	Molecular weight (<500Da)	412.69		Yes
			LogP (<5)	6.9
			H-Bond donor (5)	1
			H-bond acceptor (<10)	1
			Violations	1
9.	Gedunin	C28H34O7	Molecular weight (<500Da)	482.57		Yes
			LogP (<5)	3.7
			H-Bond donor (5)	0
			H-bond acceptor (<10)	7
			Violations	0
10.	Ciclesonide	C32H44O7	Molecular weight (<500Da)	540.69		Yes
			LogP (<5)	4.4
			H-Bond donor (5)	1
			H-bond acceptor (<10)	7
			Violations	1
11.	Ezetimibe	C24H21F2NO3	Molecular weight (<500Da)	409.43		Yes
			LogP (<5)	4.3
			H-Bond donor (5)	2
			H-bond acceptor (<10)	5
			Violations	1
12	Meldenin	C28H38O5	Molecular weight (<500Da)	454.60		Yes
			LogP (<5)	4.4
			H-Bond donor (5)	1
			H-bond acceptor (<10)	5
			Violations	0
13	Magnolol	C18H18O2	Molecular weight (<500Da)	266.33		Yes
			LogP (<5)	4.2
			H-Bond donor (5)	2
			H-bond acceptor (<10)	5
			Violations	0
14	Pioglitazone	C19H20N2O3S	Molecular weight (<500Da)	356.44		Yes
			LogP (<5)	3.1
			H-Bond donor (5)	1
			H-bond acceptor (<10)	4
			Violations	0
15.	Gloriosine	C21H23NO6	Molecular weight (<500Da)	385.41		Yes
			LogP (<5)	2.1
			H-Bond donor (5)	1
			H-bond acceptor (<10)	6
			Violations	0