Table 3.

MM/GBSA BFE of protease inhibitors and promising drugs to interfere with SARS-CoV-2 3CL^pro and RdRp activities.

3Clpro		RdRp
Drug Name	MM/ GBSA BFE (kcal/mol)	Drug Name	MM/ GBSA BFE (kcal/mol)
Tetracycline	−15.19 ± 2.76	Ergotamine	−24.65 ± 3.93
Dihydroergotamine	−16.22 ± 5.41	Eltrombopag	−35.33 ± 3.48
Dutasteride	−20.47 ± 6.29	Conivaptan	−23.83 ± 5.43
Nelfinavir	−26.28 ± 4.48	Tipranavir	−26.08 ± 3.86
Paliperidone	−18.23 ± 4.17
4F4	−16.71 ± 4.66
4F5	−24.96 ± 3.63