Table 2.

Major clinical outcome measures for myasthenia gravis trials

Outcome	Description	Score
MG-ADL	8-item patient-completed assessment of common symptoms with severity rated 0–3	0–24 2-point improvement considered meaningful
QMG	13-item scoring system performed by trained rater of ocular, bulbar, extremity, axial, and respiratory muscles involved in MG with severity rated 0–3 based on objective criteria	0–39 3-point change considered meaningful
MG Composite	10-item MGC contains mix of examiner- and patient-based assessments of ocular, bulbar/facial/neck, respiratory, limb domains with more critical domains weighed more heavily	0–51 3-point change considered meaningful
MGFA Clinical Classification*	Ordinal scale of 5 categories of clinical severity ranging from ocular (1) to myasthenic crisis (5) and subdivisions of bulbar predominance	Class 1: ocular Class 2: mild Class 3: moderate
MG-QOL15r	15-item patient-reported assessment with rating of ‘not at all’, ‘somewhat’, and ‘very much’	0–45 not at all: 0 somewhat: 1 very much: 2

MG myasthenia gravis, MG-ADL Myasthenia Gravis Activities of Daily Living, MGFA MG Foundation of America, MG-QOL15r MG-Quality of Life–revised, QMG Quantitative Myasthenia Gravis

*MGFA Classification is no longer considered an outcome measure, but was used in some studies in this manner prior to 2000