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. 2020 Aug 29;17(15):2387–2395. doi: 10.7150/ijms.48615

Figure 3.

Figure 3

The associations of CHD1L and METAP2 expression in EOC cells. A. A total of 11 genes were differentially expressed by more than 2-fold in ES2-shCHD1L-1 cells compared with that in ES2-shControl cells. Eight genes were found to be downregulated (CD82, METAP2, NME4, RORB, CXCL12, TSHR, MMP11 and ITGA7) and another three genes were found to be upregulated (TNFSF10, CDH11 and MMP3), as detected using the Human Tumor Metastasis RT² Profiler™ PCR Array (Super Array Bioscience, America). B. Silencing of CHD1L by shRNA down-regulated CD82, METAP2 and NME4 expression in ES2-shCHD1L-1 cells, while up-regulated TNFSF10 expression in ES2-shCHD1L-1 cell, as detected by Western blotting. C. The associations of CHD1L and METAP2 expression in EOC patients. Overexpression of CHD1L and high-level expression of METAP2 were detected by IHC in an ovarian carcinoma (case 140), in which more than 80% of carcinoma cells showed strong positive staining of these proteins.