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. 2020 Jul 29;17(14):2095–2103. doi: 10.7150/ijms.45842

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Treatment of tBHQ mitigates CCL4 induced acute hepatic damage. Representative micrographs from and necrotic areas in control mice, Vehicle+CCL4, tBHQ+CCL4 and single tBHQ according to hematoxyl in and eosin staining of hepatic sections. The arrows in images are labeled as necrotic area. CCL4 induced markedly necrosis while tBHQ decreased area of necrosis (A). The necrotic areas of each group were statistical analyzed (B). The serum activities of alanine aminotransferase (C) and aspartate aminotransferase (D) in CCL4 and/or tBHQ treated mice. Magnification 200x. Arrows imply area of liver necrosis. Data are expressed as mean ± SEM (n = 6). *p < 0.05 vs. control; #p < 0.05 vs. the CCL4 group.