Table 5.
The top 10 hub genes and their most relevant functions
| Symbol | Gene name | Degree | Relevant function | Reference |
|---|---|---|---|---|
| ITGAM | integrin subunit alpha M | 78 | A poor prognostic factor in MM and AML patients; | 57-61 |
| MMP9 | Matrix metallopeptidase 9 | 64 | Participates in the breakdown of extracellular matrix; Promotes invasion of MM; | 73, 79-84 |
| ITGB2 | Integrin subunit beta 2 | 62 | Involved in cell adhesion and cell-surface mediated signaling; Associated with drug resistance to chemotherapy in MM cell line; |
63, 66 |
| FPR2 | Formyl-peptide receptor-2 | 52 | Associated with invasion and metastasis of some cancers; | 96-98 |
| C3AR1 | complement C3a receptor 1 | 51 | Involved in drug resistance to chemotherapy in AML cell; Predicts overall survival of AML; |
99 |
| CXCL1 | C-X-C motif chemokine ligand 1 | 51 | Associated with the growth and progression of some cancers; | 100-102 |
| CYBB | cytochrome b-245 beta chain | 48 | Involved in the progression of some cancers by promotion of angiogenesis; | 103, 104 |
| LILRB2 | leukocyte immunoglobulin like receptor B2 | 46 | Inhibits stimulation of an immune response; Promotes tumor progression; | 105-107 |
| HP | haptoglobin | 44 | NA | - |
| FCER1G | Fc fragment of IgE receptor Ig | 43 | Associated with disease progression in lymphoma and some solid cancers; Deficient expression represents T-cell immunodeficiency in CLL. |
108-110 |