Table 4.
Summary outcomes of patients according to the ISAPL modeling, considering the original data and bootstrap resampling
| Clinical end points | 1 y, % of mean (95% CI) | 2 y, % of mean (95% CI) | 5 y, % of mean (95% CI) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Low ISAPL | High ISAPL | P | Low ISAPL | High ISAPL | P | Low ISAPL | High ISAPL | P | |
| OS | — | — | <.001* | — | — | <.001* | — | — | <.001* |
| Original data | 91 (82-95) | 67 (55-76) | — | 91 (82-96) | 67 (55-76) | — | 91 (82-95) | 55 (40-68) | — |
| Bootstrap resampling | 91 (83-96) | 67 (56-77) | — | 91 (83-96) | 67 (56-77) | — | 91 (83-96) | 55 (38-67) | — |
| DFS | — | — | <.001† | — | — | <.001* | — | — | <.001* |
| Original data | 98 (90-100) | 88 (74-95) | 92 (82-97) | 85 (70-93) | — | 90 (78-95) | 72 (53-84) | — | |
| Bootstrap resampling | 98 (92-100) | 88 (74-96) | 92 (82-97) | 85 (71-94) | — | 90 (81-96) | 72 (51-84) | — | |
| EFS | — | — | <.001* | — | — | <.001* | — | — | <.001* |
| Original data | 91 (82-95) | 63 (51-73) | — | 85 (75-91) | 60 (47-70) | — | 83 (73-90) | 45 (31-58) | — |
| Bootstrap resampling | 91 (81-96) | 63 (52-75) | — | 85 (76-92) | 60 (48-71) | — | 84 (74-90) | 44 (32-60) | — |
| CIR | — | — | <.001† | — | — | <.001* | — | — | <.001* |
| Original data | 2 (0-8) | 10 (3-21) | — | 7 (2-17) | 13 (4-23) | 9 (2-17) | 25 (11-39) | — | |
| Bootstrap resampling | 1 (0-9) | 11 (4-22) | — | 8 (3-17) | 14 (4-25) | 9 (4-19) | 25 (14-43) | — | |
*
Welch 2-sample Student t test.
†
The Wilcoxon-Mann-Whitney test was used because of the instability caused by extreme values.