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. 2020 Sep 10;10:14923. doi: 10.1038/s41598-020-71947-2

Table 6.

Correlation of complement proteins with clinical parameters in dengue patients.

C2 (µg/ml) C4b (µg/ml) C5 (µg/ml) C5a (µg/ml) C9 (µg/ml) Factor D (µg/ml) MBL (µg/ml) Factor I (µg/ml) AST (IU/ml) ALT (IU/ml) RBC (× 103/ml) WBC (× 106/ml) PLT (× 103/ml) HCT (%)
C2 (µg/ml)
rs 0.5 0.39 0.61 0.052 − 0.25 0.004 0.02 0.14 0.13 − 0.09 0.16 0.07 − 0.12
P < 0.0001 < 0.0001 < 0.0001 0.51 0.002 0.96 0.79 0.09 0.11 0.27 0.04 0.38 0.14
C4b (µg/ml)
rs 0.35 0.52 0.38 0.08 − 0.15 − 0.09 0.19 − 0.1 − 0.04 − 0.15 0.06 0.25 − 0.12
P < 0.0001 < 0.0001 < 0.0001 0.29 0.06 0.23 0.014 0.22 0.66 0.053 0.45 0.002 0.15
C5 (µg/ml)
rs 0.17 0.37 0.37 0.32 0.04 − 0.11 0.12 0.03 0.003 0.03 0.09 0.03 0.03
P 0.08 < 0.0001 < 0.0001 < 0.0001 0.58 0.16 0.45 0.69 0.97 0.72 0.23 0.76 0.76
C5a (µg/ml)
rs 0.62 0.32 0.34 − 0.17 − 0.34 0.07 − 0.06 0.16 0.1 0.02 0.06 − 0.03 0.01
P < 0.0001 0.001 0.001 0.03 < 0.0001 0.39 0.46 0.64 0.23 0.81 0.43 0.67 0.9
C9 (µg/ml)
rs − 0.24 − 0.14 0.18 − 0.31 0.21 − 0.05 0.12 − 0.044 − 0.001 0.015 − 0.02 0.09 0.005
P 0.02 0.18 0.08 0.002 0.01 0.51 0.12 0.6 0.99 0.86 0.79 0.26 0.95
Factor D (µg/ml)
rs − 0.5 − 0.23 0.09 − 0.53 0.49 − 0.17 0.145 0.09 0.06 0.31 − 0.24 − 0.31 0.32
P < 0.0001 0.03 0.39 < 0.0001 < 0.0001 0.034 0.69 0.34 0.61 < 0.0001 0.002 < 0.0001 < 0.0001
MBL (µg/ml)
rs 0.18 0.06 0.11 0.16 − 0.17 − 0.12 − 0.04 − 0.01 0.01 − 0.08 − 0.05 0.11 − 0.02
P 0.07 0.54 0.29 0.11 0.09 0.23 0.59 0.9 0.94 0.31 0.58 0.17 0.71
Factor I (µg/ml)
rs 0.12 0.29 0.24 − 0.05 0.09 0.25 0.06 − 0.13 − 0.15 − 0.08 − 0.005 0.15 − 0.1
P 0.23 0.004 0.02 0.62 0.38 0.01 0.53 0.14 0.06 0.34 0.95 0.065 0.24
AST (IU/ml)
rs 0.27 0.07 − 0.02 0.22 − 0.18 − 0.25 − 0.12 0.02 0.87 0.28 − 0.03 − 0.46 0.23
P 0.012 0.54 0.88 0.04 0.09 0.02 0.29 0.8 < 0.0001 < 0.0001 0.75 < 0.0001 0.005
ALT (IU/ml)
rs 0.32 0.14 − 0.001 0.3 − 0.27 − 0.25 − 0.03 0.04 0.91 0.27 0.09 − 0.34 0.21
P 0.002 0.2 0.99 0.005 0.01 0.015 0.8 0.7 < 0.0001 0.001 0.27 < 0.0001 0.008
RBC (× 103/ml)
rs 0.11 − 0.22 0.03 0.03 0.04 0.18 0.02 0.05 0.001 0.07 0.006 − 0.3 0.87
P 0.28 0.03 0.79 0.8 0.7 0.08 0.85 0.66 0.99 0.5 0.94 < 0.0001 < 0.0001
WBC (× 106/ml)
rs 0.24 0.04 0.02 0.25 − 0.23 − 0.16 0.18 0.25 0.26 0.36 0.25 0.26 0.04
P 0.02 0.7 0.86 0.012 0.02 0.11 0.07 0.014 0.013 < 0.0001 0.009 < 0.0001 0.61
PLT (× 103/ml)
rs − 0.08 0.14 0.11 0.05 − 0.05 − 0.22 − 0.07 − 0.05 − 0.1 − 0.007 − 0.26 − 0.09 − 0.28
P 0.43 0.14 0.29 0.6 0.6 0.026 0.5 0.63 0.32 0.94 0.006 0.36 < 0.0001
HCT (%)
rs 0.004 − 0.24 0.03 − 0.07 − 0.04 0.18 − 0.02 0.05 0.04 0.08 0.86 0.26 − 0.32
P 0.97 0.17 0.78 0.68 0.68 0.067 0.87 0.6 0.7 0.4 < 0.0001 0.006 0.001

Spearman’s rho (rs) calculated by Spearman's rank correlation coefficient. rs and P values in the upper-right area are the correlation between variables in dengue patients. rs and P values in the lower-left area are the correlation between variables in dengue patients with warning signs (DWS).

Bold rs and P values indicate a significant and strong correlation between variables.

AST and ALT aspartate and alanine amino transferase, WBC white blood cells, RBC red blood cells, PLT platelets, HCT haematocrit, IU international unit.