Fig. 3. MFG-E8 deficiency enhances inflammatory response at the wound sites of diabetic mice.

a–c Statistical analysis of total CD11b⁺ cells a, CD11b⁺ Ly6G⁺ neutrophils b, and CD11b⁺ F4/80⁺ macrophages c in PVA wound sites of WT or Mfge8^−/− (n = 6) mice treated with vehicle or STZ post-wounding at day 0, 3, 7, and 14. d–f Inflammatory cytokine profiles response to wound. The serum levels of IL-1β d, IL-18 e, and TNF-α f from WT or Mfge8^−/− mice (n = 6) treated with vehicle or STZ post-wounding at day 0, 3, 7, and 14 were measured with ELISA. g–j Cytokine profiles in wound site. The concentration of IL-1β g, IL-18 h, TNF-α i, and IL-10 j in PVA from wound skins of WT or Mfge8^−/− mice (n = 6) treated with vehicle or STZ post-wounding at day 3 were determined with ELISA. For all experiments, data are presented as mean ± SEM, *P < 0.05, **P < 0.01, ***P < 0.001.