Fig. 2. Spaghetti plots of DNA methylation age versus chronological ages in the longitudinal Enroll-HD data 2.

Each spaghetti plot depicts DNAm age versus chronological age, using the Enroll-HD data 2 with two time-points per individual. Each line connects two blood draws from the same individual collected on average 7.9 years apart. The panels report results for different epigenetic clocks a Horvath’s pan-tissue clock¹⁴, b Hannum’s blood-based clock¹⁵, c the skin and blood clock¹⁶, and d and DNAm PhenoAge¹⁷. The same analysis was not performed on DNAmGrimAge because it is a mortality risk predictor that uses age in its definition.