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. 2020 Sep 10;11:4529. doi: 10.1038/s41467-020-18255-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — The product of the two CAG alleles (CAG.product = CAG.long × CAG.short) correlated with DNA methylation levels of the human HTT cg22982173 locus in a blood samples from Enroll-HD data 1, b blood samples from Enroll-HD data 2, c blood samples from the Registry-HD study, d lymphoblastoid lines from the Registry-HD study, and e fibroblast samples from the MTM study. The title of each panel reports the Pearson’s correlation coefficient and corresponding unadjusted p value. Fixed-effects meta-analysis (weighted by inverse variance) produced a meta-analysis p value of 9.1 × 10⁻¹²³. Points in the scatter plots are colored by HD status: red = manifest HD, orange = pre-manifest HD, and black = control. Each plot reports a Pearson’s correlation coefficient and corresponding p value.