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. 2020 Sep 10;11:4527. doi: 10.1038/s41467-020-18372-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, b CNA expressed as frequency in TRACERx LUAD grouped for TP53 wild-type (WT) (a) and mutant (b). Shading indicates clonal status. n = number of patients. c Frequency distribution of MCL-1 gain in TP53 wild-type or clonal mutant TRACERx LUAD patients. Data were analysed by Pearson’s chi-squared test with continuity correction (p = 0.007, chi-square(2) = 9.885). d Comparison of MCL-1- segment sizes between clonal and subclonal MCL-1 gains for TP53 mutant and WT samples. Two-sided Wilcoxon testing showed no significant differences. TP53 mut n = 54 (34 clonal and 20 subclonal gains, p = 0.89, W = 348) TP53 WT n = 69 (57 clonal and 12 subclonal gains, p = 0.53, W = 302). n = number of samples. The data are presented as box plot, where the centre line represents the median value, the limits represent the 25th and 75th percentile, the whiskers represent the minimum and maximum value of the distribution, and the points represent the individual experimental values.