Table 2.
Twenty most abundant proteins in HC and HC + SC samples and 20 most abundant SC proteins on SNPs and PsNPs.
| No. | Top 20 proteins in HC samples | Top 20 proteins in HC + SC samples | Top 20 proteins in SC | Fold increase |
|---|---|---|---|---|
| SNPs | ||||
| 1 | APO-AI/46% | APO-AI/40.5% | APOH | 5.71 |
| 2 | Hemoglobin fetal subunit beta/8.7% | Hemoglobin fetal subunit beta/8.9% | Complement C4 | 6.22 |
| 3 | Serum albumin/4.3% | Serum albumin/4.3% | UP2 | New |
| 4 | Hemoglobin subunit alpha/4% | Hemoglobin subunit alpha/4% | UP3 | New |
| 5 | Alpha-1-antiproteinase | Alpha-1-antiproteinase | UP1 | 3.31 |
| 6 | Kininogen-1 | Tetranectin | Cystatin-C | New |
| 7 | Plasminogen | Alpha-2-HS-glycoprotein | Fibulin-1 | 2.80 |
| 8 | Histidine-rich glycoprotein | Plasminogen | Collagen alpha-2(I) chain | 4.09 |
| 9 | Alpha-2-HS-glycoprotein | APOH | SERPINA11 protein | New |
| 10 | Apolipoprotein E | Serotransferrin | Fibronectin | 2.36 |
| 11 | Antithrombin-III | Histidine-rich glycoprotein | Alpha-S1-casein | 1.96 |
| 12 | Alpha-fetoprotein | Kininogen-1 | Thrombospondin-1 | 1.81 |
| 13 | Serotransferrin | Antithrombin-III | Complement C3 | 1.87 |
| 14 | Alpha-2-macroglobulin | Apolipoprotein E | Inter-alpha-trypsin inhibitor H3 | 1.60 |
| 15 | Protein S100-A12 | Alpha-2-macroglobulin | Inter-alpha-trypsin inhibitor H2 | 1.71 |
| 16 | Kininogen-2 | Alpha-fetoprotein | Hemopexin | 1.61 |
| 17 | Hemoglobin subunit beta | Insulin-like growth factor-binding 2 | Pigment epithelium-derived factor | 1.48 |
| 18 | Actin, cytoplasmic 1 | Apolipoprotein M | Prothrombin | 1.22 |
| 19 | Prothrombin | Complement C3 | Antithrombin-III | 1.32 |
| 20 | Apolipoprotein M | Hemoglobin subunit beta | Alpha-2-macroglobulin | 1.25 |
| PsNPs | ||||
| 1 | Serum albumin/24.2% | Serum albumin/22.3% | Angiotensinogen | 2.19 |
| 2 | Hemoglobin fetal subunit beta/20.3% | Hemoglobin fetal subunit beta/20.3% | Alpha-1-antiproteinase | 1.57 |
| 3 | Hemoglobin subunit alpha/3.8% | APO-AI/3.8% | Serpin family G member 1 | 2.35 |
| 4 | APO-AI/9.2% | Hemoglobin subunit alpha/3.7% | Serotransferrin | 1.59 |
| 5 | Plasminogen | Plasminogen | Tetranectin | 9.47 |
| 6 | Alpha-fetoprotein | Alpha-fetoprotein | Plasma serine protease inhibitor | 1.61 |
| 7 | Alpha-2-HS-glycoprotein | Alpha-1-antiproteinase | Cystatin -C | 22.22 |
| 8 | Alpha-1-antiproteinase | Serotransferrin | Complement factor I | 23.39 |
| 9 | Kininogen-1 | Angiotensinogen | Alpha-2-macroglobulin | 1.59 |
| 10 | Serotransferrin | Kininogen-1 | Complement factor H | 1.67 |
| 11 | Apolipoprotein E | Antithrombin-III | Insulin-like growth factor-binding 2 | 1.55 |
| 12 | Beta-2-glycoprotein 1 | Plasma serine protease inhibitor | Plasma kallikrein | 1.51 |
| 13 | Alpha-S1-casein | APOH | Secreted phosphoprotein 24 | 2.66 |
| 14 | Plasma serine protease inhibitor | Serpin family G member 1 | Fetuin-B | 1.33 |
| 15 | Kininogen-2 | Alpha-2-HS-glycoprotein | Hemopexin | 4.93 |
| 16 | Antithrombin-III | Sulfhydryl oxidase | Coagulation factor XII | 1.81 |
| 17 | Fetuin-B | Apolipoprotein E | Kininogen-2 | 1.25 |
| 18 | Actin, cytoplasmic 1 | Fetuin-B | Protein AMBP | 1.28 |
| 19 | Angiotensinogen | Kininogen-2 | Ig-like domain-containing protein | 11.98 |
| 20 | Beta-lactoglobulin | Alpha-2-macroglobulin | Fibulin-1 | 5.34 |
Entries in italics are the proteins among the 20 most abundant proteins that appear to be in both HC- and SC-binding states.