Table 4.
Logistic regression results for hospital mortality of patients who underwent surgical repair for uncomplicated acute type A aortic dissection.
| Parameters | β-Coefficient | Standard error | Odds ratio, 95% CI | P-value | Adjusted for sparse data bias |
|---|---|---|---|---|---|
| Univariate logistic regression | |||||
| Repeat surgery | 2.014 | 0.592 | 7.49 (2.35–23.92) | < 0.001 | Before |
| 1.459 | 0.465 | 4.30 (1.73–10.70) | 0.002 | After | |
| Cardiopulmonary bypass time > 274 mina | 1.870 | 0.429 | 6.49 (2.80–15.03) | < 0.001 | Before |
| 1.567 | 0.352 | 4.79 (2.41–9.55) | < 0.001 | After | |
| Aortic clamping time > 179 minb | 1.489 | 0.402 | 4.43 (2.02–9.75) | < 0.001 | Before |
| 1.298 | 0.343 | 3.66 (1.87–7.17) | < 0.001 | After | |
| Circulatory arrest time > 63 minc | 1.334 | 0.381 | 3.80 (1.80–8.01) | < 0.001 | Before |
| 1.190 | 0.334 | 3.29 (1.71–6.32) | < 0.001 | After | |
| RCP | 2.040 | 0.474 | 7.69 (3.04–19.48) | < 0.001 | Before |
| 1.618 | 0.400 | 6.27 (2.89–13.63) | < 0.001 | After | |
| Hypothermia temperature < 22 °Cd | 1.253 | 0.623 | 3.50 (1.03–11.87) | 0.044 | Before |
| 1.020 | 0.446 | 2.77 (1.16–6.64) | 0.022 | After | |
| ECMO support | 3.186 | 1.171 | 24.20 (2.44–240.11) | 0.007 | Before |
| 1.940 | 0.581 | 6.96 (2.23–21.74) | < 0.001 | After | |
| Renal failure | 2.040 | 0.474 | 7.69 (3.04–19.48) | < 0.001 | Before |
| 1.618 | 0.400 | 5.04 (2.30–11.04) | < 0.001 | After | |
| Brain stroke | 0.835 | 0.432 | 2.31 (0.99–5.38) | 0.053 | Before |
| 0.602 | 0.379 | 1.83 (0.85–3.76) | 0.112 | After | |
| Axillary arterial cannulation | − 1.754 | 0.455 | 0.17 (0.07–0.42) | < 0.001 | – |
| Isolated AsAo replacement | − 0.840 | 0.380 | 0.43 (0.21–0.91) | 0.027 | – |
| Arch replacement | 0.804 | 0.376 | 2.24 (1.07–4.67) | 0.032 | – |
| Total arch | 1.479 | 0.414 | 4.39 (1.95–9.88) | < 0.001 | – |
| ACP | − 2.040 | 0.474 | 0.13 (0.05–0.33) | < 0.001 | – |
| Malperfusion-related complications | 1.367 | 0.384 | 3.93 (1.85–8.34) | < 0.001 | – |
| Multivariate logistic regression | |||||
| Repeat surgery | 1.614 | 0.727 | 5.02 (1.21–20.86) | 0.026 | Before |
| 1.101 | 0.505 | 3.01 (1.12–8.09) | 0.029 | After | |
| Cardiopulmonary bypass time > 274 mina | 1.443 | 0.739 | 4.24 (0.99–18.03) | 0.051 | Before |
| 0.795 | 0.459 | 2.21 (0.90–5.45) | 0.084 | After | |
| Aortic clamping time > 179 minb | 0.066 | 0.707 | 1.07 (0.27–4.28) | 0.925 | Before |
| 0.266 | 0.455 | 1.31 (0.54–3.18) | 0.559 | After | |
| Circulatory arrest time > 63 minc | 0.570 | 0.541 | 1.77 (0.61–5.11) | 0.292 | Before |
| 0.423 | 0.410 | 1.53 (0.68–3.41) | 0.302 | After | |
| RCP | 2.249 | 0.602 | 9.48 (2.92–30.84) | < 0.001 | Before |
| 1.803 | 0.443 | 6.07 (2.55–14.47) | < 0.001 | After | |
| Hypothermia temperature < 22 °Cd | 0.272 | 0.760 | 1.31 (0.29–5.82) | 0.721 | Before |
| 0.545 | 0.506 | 1.73 (0.64–4.65) | 0.281 | After | |
| ECMO support | 3.143 | 1.280 | 23.18 (1.89–284.87) | 0.014 | Before |
| 1.842 | 0.594 | 6.31 (1.97–20.19) | 0.002 | After | |
| Renal failure | 0.782 | 0.766 | 2.19 (0.49–9.81) | 0.308 | Before |
| 0.957 | 0.723 | 2.60 (0.63–10.74) | 0.186 | After | |
| Isolated AsAo replacement | 0.231 | 0.877 | 1.26 (0.23–7.02) | 0.792 | – |
| Arch replacement | 0.339 | 0.983 | 1.40 (0.21–9.63) | 0.730 | – |
| Total arch | 1.017 | 0.716 | 2.76 (0.68–11.25) | 0.156 | – |
| Malperfusion-related complications | 0.449 | 0.607 | 1.57 (0.48–5.14) | 0.460 | – |
ACP antegrade cerebral perfusion, AsAo ascending aorta, AUROC area under the receiver operating characteristics curve, ECMO extracorporeal membrane oxygenation, RCP retrograde cerebral perfusion.
aAUROC 0.736; sensitivity 75.8%; specificity 67.5%; Youden Index 0.433.
bAUROC 0.686; sensitivity 69.7%; specificity 65.8%; Youden Index 0.355.
cAUROC 0.644; sensitivity 57.6%; specificity 73.7%; Youden Index 0.313.
dAUROC 0.616; sensitivity 90.9%; specificity 23.0%; Youden Index 0.139.