Cohort histograms: % time with combined PRx and PbtO2 derangements. (A) Histogram of % time with PRx >0 and PbtO2 < 20 mm Hg. (B) Histogram of % time with PRx >0 and PbtO2 > 20 mm Hg. (C) Histogram of % time with PRx < below 0 and PbtO2 < 20 mm Hg. (D) Histogram of % time with PRx > +0.25 and PbtO2 < 20 mm Hg. (E) Histogram of % time with PRx > +0.25 and PbtO2 > 20 mm Hg. (F) Histogram of % time with PRx < +0.35 and PbtO2 < 20 mm Hg. Mean and % time values were derived across the patient's entire recording period. Frequency, number of patients; ICP, intracranial pressure; MAP, mean arterial pressure; PbtO2, brain tissue oxygen; PRx, pressure reactivity index (correlation between slow waves of ICP and MAP).