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Covariate analysis. The coefficient of determination for body surface area (BSA) and the estimated clearance (a, R 2 = 0.54) is a stronger relationship than the coefficient of determination for weight allometrically scaled to 70 kg and the estimated clearance (b, R 2 = 0.25). Serum creatinine demonstrated a nonlinear with clearance normalized to BSA (c). The gray dots represent clearance estimates at the first serum creatinine level for each patient course.
