Table 3.
Final model parameter estimates
| Parameters | Mean | Relative standard error (%) | Interindividual variability | Relative standard error (%) |
|---|---|---|---|---|
| CL, L/h/1.73 m2 | 11 | 0.7 | 0.08 | 4.7 |
| V1, L/1.73 m2 | 16.5 | 5.2 | 0 FIX | – |
| Q2, L/h/1.73 m2 | 0.602 | 4.1 | 0 FIX | – |
| V2, L/1.73 m2 | 4.55 | 3.4 | 0.12 | 4.3 |
| Q3, L/h/1.73 m2 | 0.111 | 2 | 0.13 | 6.7 |
| V3, L/1.73 m2 | 13.1 | 5 | 0.10 | 14.4 |
| SCr | −0.247 | 5.7 | – | – |
CL, clearance of methotrexate from the central compartment; Q2, inter‐compartmental clearance for vascular peripheral compartment; Q3, intercompartmental clearance for the nonvascular compartment; SCr, pharmacokinetic estimate for serum creatinine; V1, volume of distribution of methotrexate in the central compartment; V2, volume of distribution of methotrexate in the vascular compartment; V3, volume of distribution of methotrexate in the nonvascular compartment.