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. Author manuscript; available in PMC: 2020 Sep 11.
Published in final edited form as: Nat Genet. 2020 Jan 20;52(2):167–176. doi: 10.1038/s41588-019-0567-8

Extended Data Fig. 9. Presence of colocalizing association signals for urinary metabolites and phenotypes and diseases in the UK Biobank.

Extended Data Fig. 9

Colocalizing associations (H4≥0.8, Methods) that showed associations at genome-wide significance (P<5e-8) with both metabolites and traits and diseases in the UK Biobank were found between 68 traits and 66 of the index SNPs. The strength of the associations based on their association P values with the UK Biobank trait are indicated by cross or asterisk as described in the legend. The traits are sorted into five groups: blood count-based parameters, anthropometry, lifestyle, medical conditions, and skin color (left to right). SNPs are sorted by gene and within gene by position. Genes where incorporation of existing biochemical and biological knowledge would have led to prioritization of another most likely causal gene are marked with a # (see Supplementary Note).