FIGURE 3.

Peptidomimetics PM1 and PM2 attenuated the production of proinflammatory chemokines MCP-1 and CXCL-1 and cytokine IL-6 in PMA-inflamed ear tissue. CD-1 mice were treated as described in Figure 2. Mice ear biopsies (5 mm in diameter) were harvested, homogenized and centrifuged to collect supernatants for determining MCP-1, CXCL-1, and IL-6 levels 6 h post PM1 (A) or PM2 (B) treatment by ELISA. Each condition was repeated with a total of five to eight mice in four independent experiments. Error bars indicate Mean ± SD. Statistics: *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001, and Student’s unpaired t-test.