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. 2020 Aug 28;11:2102. doi: 10.3389/fimmu.2020.02102

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Copyright © 2020 Wu, Skovbakke, Masoudi, Hancock and Franzyk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Peptidomimetics PM1 and PM2 suppressed neutrophil infiltration in to the ear tissue. (A) A representative image of H&E stained ear tissue biopsies from a total of three to six biological replicates (three independent experiments) per treatment group is shown. (B) Ear edema pathology scores (0: no edema, 1: mild, 2: moderate, and 3: severe) were assigned. The number of each type of immune cells present in the stained specimen was determined (cells/HPF): (C) neutrophils, (D) monocytes, (E) eosinophils, and (F) lymphocytes. Error bars indicate Mean ± SD. Statistics: *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001, one-way ANOVA, and Dunnett’s multiple comparisons test.