Table 5.

List of investigations in PIMS-TS.

Blood tests	Blood gas with lactate Full blood count and film Renal profile Liver function tests, LDH, Triglycerides, CK Amylase in presence of abdominal symptoms C-reactive protein, procalcitonin, ferritin, ESR Coagulation screen with fibrinogen and D-Dimer Troponin, pro-BNP Vitamin D
Imaging	Chest X ray ECG, echocardiogram Abdominal US with abdominal symptoms
Microbiology and virology	Blood culture Urine culture Stools culture Throat culture Nasopharyngeal aspirate or throat swab for PCR for respiratory viruses Mycoplasma pneumoniae titres, ASOT PCR for bacterial pathogens (e.g., meningococcal, pneumococcal, streptococcal, and staphylococcal PCR) on blood PCR for EBV, CMV, adenovirus, parvovirus, enterovirus, and parechovirus on blood HIV Save samples for PCR and serology studies (prior to IVIG)
SARS-CoV-2 investigations	SARS-CoV-2 Respiratory PCR; Consider PCR on stools and blood SARS-CoV-2 serology

Proposed list of initial investigations in children with suspected PIMS-TS needing hospital admission. This list is not exhaustive and additional investigations should be tailored to each individual patient.

Anti-Streptolysin O Titer; CK, Creatine Kinase; EBV, Epstein-Barr Virus; ECG, electrocardiogram; ESR, Erythrocyte Sedimentation Rate; HIV, Human Immunodeficiency Virus; LDH, lactate dehydrogenase; PCR, Polymerase Chain Reaction; pro-BNP, pro-Brain Natriuretic Peptide; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; US, Ultrasound.