Table 3.
Wet-to-dry-weight ratio and histological analyses
Variable | control | AT i.v. | triple |
---|---|---|---|
Wet-to-dry-weight ratio | 5.9 ± 0.2 | 4.9 ± 0.3† | 4.8 ± 0.2† |
Obstruction bronchi (score) | 11.7 ± 2.2 | 4.6 ± 0.4† | 2.8 ± 0.5†# |
Obstruction bronchioli (score) | 2.6 ± 0.3 | 1.0 ± 0.2† | 1.1 ± 0.2† |
Alveolar edema (score) | 1.0 ± 0.3 | 0.3 ± 0.1† | 0.4 ± 0.1 |
Pulmonary PMN (score) | 0.29 ± 0.08 | 0.06 ± 0.05† | 0.13 ± 0.06 |
p<0.05 vs. control;
p<0.05 vs. AT i.v.; each group n = 6
AT i.v., intravenous recombinant human antithrombin III; PMN, polymorphonuclear cells triple, recombinant human antithrombin III i.v., nebulized heparin and nebulized tissue plasminogen activator