TABLE 2.

Methylation differences of S100P between BC cases and controls in Study I stratify by median of age.

Age	CpG sites	Controls median (IQR)	BC cases median (IQR)	OR (95% CI)* per −10% methylation	p-value*
Age ≤ 45 (case = 144 Control = 192)	S100P_CpG_2.3	0.63 (0.59–0.66)	0.64 (0.61–0.68)	0.46 (0.24–0.86)	0.016
	S100P_CpG_4	0.69 (0.66–0.74)	0.71 (0.68–0.76)	0.68 (0.42–1.12)	0.130
	S100P_CpG_7	0.40 (0.35–0.46)	0.41 (0.34–0.48)	0.81 (0.61–1.08)	0.157
	S100P_CpG_8	0.46 (0.41–0.51)	0.48 (0.42–0.54)	0.85 (0.60–1.19)	0.343
	S100P_CpG_9	0.49 (0.42–0.56)	0.49 (0.44–0.55)	0.61 (0.41–0.91)	0.014
	S100P_CpG_10.11.12	0.61 (0.57–0.64)	0.64 (0.58–0.67)	0.55 (0.35–0.88)	0.012
Age > 45 (case = 143 Control = 140)	S100P_CpG_2.3	0.65 (0.62–0.69)	0.67 (0.62–0.70)	1.39 (0.58–3.34)	0.458
	S100P_CpG_4	0.72 (0.68–0.76)	0.71 (0.68–0.76)	0.76 (0.40–1.46)	0.407
	S100P_CpG_7	0.43 (0.36–0.51)	0.42 (0.35–0.46)	1.33 (0.89–1.99)	0.163
	S100P_CpG_8	0.50 (0.44–0.54)	0.51 (0.43–0.57)	1.49 (0.93–2.39)	0.102
	S100P_CpG_9	0.55 (0.46–0.59)	0.58 (0.48–0.64)	0.77 (0.44–1.35)	0.358
	S100P_CpG_10.11.12	0.63 (0.60–0.67)	0.64 (0.61–0.68)	0.89 (0.48–1.66)	0.717

*Logistic regression, adjusted for age and batches of measurement. BC, breast cancer; S100P, S100 calcium-binding protein P gene; OR, odds ratio; IQR, interquartile range. The bold values indicate p < 0.05.