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. 2020 Aug 28;11:1325. doi: 10.3389/fphar.2020.01325

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Copyright © 2020 Zhu, Liu, Liu, Chen, Liu and Yin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Effects of hesperidin on the depression-like behaviors of diabetic rats in the forced swimming test (FST). (B) Effects of hesperidin on spontaneous locomotor activity in diabetic rats subjected to the locomotor activity test (LCMT). (C) Effects of hesperidin on serum corticosterone levels in diabetic rats. Cont, DM, Hsd-L, Hsd-H, and tert-butylhydroquinone (TBHQ) represent the control rats, STZ-induced diabetic rats (DM), control or diabetic rats treated with hesperidin at low and high (50, 150 mg/kg) doses, and diabetic rats treated with the Nrf2 activator TBHQ (25 mg/kg), respectively. The results are presented as the mean ± S.E.M., n = 10–11 (FST and LCMT) or n = 7–8 (corticosterone). ^***p < 0.001, vs. Cont group; ^#p < 0.05, ^##p < 0.01, ^###p < 0.001, vs. DM group.