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. 2020 Aug 28;11:1325. doi: 10.3389/fphar.2020.01325

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Copyright © 2020 Zhu, Liu, Liu, Chen, Liu and Yin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of hesperidin on the anxiolytic-like behaviors of diabetic rats in the open field test (OFT) and elevated plus maze (EPM). (A) Latency time to the center area of the OFT. (B) Time spent in the center area of the OFT. (C) Entrance into the open arms of the EPM. (D) Time spent in the open arms of the EPM. Cont, DM, Hsd-L, Hsd-H, and tert-butylhydroquinone (TBHQ) represent the control rats, streptozotocin (STZ)-induced diabetic rats (DM), control or diabetic rats treated with hesperidin at low and high (50, 150 mg/kg) doses, and diabetic rats treated with the Nrf2 activator TBHQ (25 mg/kg), respectively. The results are presented as the mean ± S.E.M., n = 10–11. ^*p < 0.01, ^**p < 0.01, vs. Cont group; ^#p < 0.05, ^##p < 0.01, ^###p < 0.001, vs. DM group.