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. 2020 Aug 28;11:1325. doi: 10.3389/fphar.2020.01325

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Copyright © 2020 Zhu, Liu, Liu, Chen, Liu and Yin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of hesperidin on the changes in neuronal pathomorphology in the hippocampus CA1 and CA3 subfield of diabetic rats (HE ×400, Scale bar = 20 μm). Cont, DM, Hsd-L, Hsd-H, and tert-butylhydroquinone (TBHQ) represent the control rats, streptozotocin (STZ)-induced diabetic rats (DM), diabetic rats treated with hesperidin at low and high (50, 150 mg/kg) doses, and diabetic rats treated with the Nrf2 activator TBHQ (25 mg/kg), respectively.