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. 2020 Aug 28;11:1325. doi: 10.3389/fphar.2020.01325

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Copyright © 2020 Zhu, Liu, Liu, Chen, Liu and Yin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The protective effects of hesperidin against high glucose (HG)-induced neurotoxicity in N2a cells. (A) Effects of hesperidin on the viability of N2a cells. (B) Treatment with ML385, an Nrf2 inhibitor, blocked the neuroprotective effects of hesperidin on the viability of HG-treated cells. (C) Effects of hesperidin on the LDH release from N2a cells. (D) Treatment with ML385, an Nrf2 inhibitor, blocked the neuroprotective effects of hesperidin on the LDH release of HG-treated cells. The results are presented as the mean ± S.E.M., n = 6. ^*** p < 0.001, vs. NG group. ^#p < 0.05, ^##p < 0.01 and ^### p < 0.001 vs. the DM group. ^$$p < 0.01 vs. Hsd (20 μM) group.