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. 2020 Sep 10;10(9):e036748. doi: 10.1136/bmjopen-2019-036748

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Forest plots of secondary outcomes: cyclo-oxygenase-2 (COX-2) inhibitors versus traditional non-steroidal anti-inflammatory drugs (NSAIDs). Response rate for (A) days 2–8, (B) C reactive protein, (C) patient’s global assessment, (D) investigator’s global assessment and (E) inflammatory swelling. bid, two times per day; qd, one time a day; tid, three times a day; vs, versus.