TABLE 3.

Adjusted^a Odds Ratios for Composite Outcome of Hospital Mortality or Initiation of Renal Replacement Therapy Associated With Neutrophil Gelatinase–Associated Lipocalin and Serum Creatinine Status^b

OR (95% CI)
Biomarker (Sampling Time)	NGAL-/SCr-	NGAL+/SCr-	NGAL-/SCr+	NGAL+/SCr+	c-Statistic (95% CI)
Uncorrected (raw) NGAL
NGAL< 1 hr post-CPB	1.00 (reference)	1.9 (0.2–13.9)	7.6 (1.5–38.8)	24.5 (5.0–122)	0.93 (0.90–0.97)
	n = 344	n = 104	n = 107	n = 46
NGAL3hr post-CPB	1.00 (reference)	4.3 (0.4–49.4)	12.3 (1.3–112)	58.6 (7.0–489)	0.94 (0.90–0.97)
	n = 351	n = 95	n = 97	n = 51
NGAL18–24 hr post-CPB	1.00 (reference)	9.9 (1.0–100)	4.7 (0.4–55.2)	74.5 (9.4–594)	0.95 (0.93–0.98)
	n = 365	n = 82	n = 90	n = 65
Corrected for urinary creatinine
NGAL< 1 hr post-CPB	1.00 (reference)	5.2 (0.5–51.8)	14.4 (1.7–122)	50.8 (6.1–424)	0.94 (0.91–0.97)
	n = 341	n = 107	n = 110	n = 43
NGAL3 hr post-CPB	1.00 (reference)	3.4 (0.3–40.6)	10.8 (1.2–99.9)	53.3 (6.5–440)	0.94 (0.90–0.97)
	n = 351	n = 95	n = 95	n = 53
NGAL18–24 hr post-CPB	1.00 (reference)	6.8 (0.7–69.9)	1.7 (0.1–29.5)	91.4 (11.3–737)	0.96 (0.93–0.99)
	n = 356	n = 91	n = 96	n = 59

OR = odds ratio, NGAL = neutrophil gelatinase–associated lipocalin, S_Cr = serum creatinine, CPB = cardiopulmonary bypass.

^aAdjusted for Euroscore, baseline estimated glomerular filtration rate < 60 mL/min/1.73 m², and duration of CPB. Euroscore calculated from modified variables defined according to data available within the medical record and institutional usage to reasonably reflect Euroscore definitions.

^bNGAL+ defined by upper quartile of urinary NGAL at each time point (NGAL > 85, > 34, and > 41 ng/mL at < 1 hr post-CPB, 3 hr post-CPB, and 18–24 hr post-CPB, respectively; corrected NGAL > 422, > 125, and > 44 ng/mg creatinine at < 1 hr post-CPB, 3 hr post-CPB, and 18–24 hr post-CPB, respectively). S_Cr + defined as acute kidney injury according to creatinine-based Kidney Disease: Improving Global Outcomes practice guidelines applied over 7 days postoperatively.Cr