. Author manuscript; available in PMC: 2020 Sep 11.

Published in final edited form as: Crit Care Med. 2015 May;43(5):1043–1052. doi: 10.1097/CCM.0000000000000927

TABLE 4.

Adjusted^a Odds Ratios for Composite Outcome of Hospital Mortality or Initiation of Renal Replacement Therapy Associated With Neutrophil Gelatinase–Associated Lipocalin/Serum Creatinine Status^b

		OR (95% CI)
Biomarker (Sampling Time)	NGAL-/S_Cr-	NGAL+/S_Cr-	NGAL-/S_Cr+	NGAL+/S_Cr+	c-Statistic (95% CI)
Uncorrected (raw) NGAL
NGAL_{< 1 hr post-CPB}	1.00 (reference)	1.0 (0.2–4.5)	3.5 (0.7–16.5)	13.7 (3.8–48.7)	0.91 (0.85–0.96)^c
	n = 313	n = 88	n = 138	n = 61
NGAL_{3 hr post-CPB}	1.00 (reference)	2.3 (0.5–10.9)	2.9 (0.4–19.9)	18.3 (4.5–75.0)	0.90 (0.84–0.96)^c
	n = 314	n = 86	n = 134	n = 59
NGAL_{18–24 hr post-CPB}	1.00 (reference)	22.6 (2.6–194)	6.2 (0.5–73.9)	71.6 (8.7–588)	0.94 (0.89–0.98)^c
	n = 379	n = 94	n = 76	n = 53
Corrected for urinary creatinine
NGAL_{< 1 hr post-CPB}	1.00 (reference)	2.8 (0.6–12.9)	7.8 (1.5–40.1)	21.6 (4.9–94.5)	0.91 (0.85–0.96)^c
	n = 311	n = 90	n = 140	n = 59
NGAL_{3 hr post-CPB}	1.00 (reference)	3.8 (0.7–20.7)	5.8 (0.9–39.5)	27.1 (5.3–140)	0.91 (0.85–0.96)^c
	n = 304	n = 96	n = 142	n = 51
NGAL_{18–24 hr post-CPB}	1.00 (reference)	17.0 (1.9–148)	2.5 (0.1–43.6)	90.1 (10.9–743)	0.94 (0.90–0.98)^c
	n = 369	n = 104	n = 83	n = 46

OR = odds ratio, NGAL = neutrophil gelatinase–associated lipocalin, S_Cr = serum creatinine, CPB = cardiopulmonary bypass.

Adjusted for Euroscore, baseline estimated glomerular filtration rate < 60 mL/min/1.73 m², and duration of CPB. Euroscore calculated from modified variables defined according to data available within the medical record and institutional usage to reasonably reflect Euroscore definitions.

NGAL+ defined by upper quartile of urinary NGAL at each time point (NGAL > 85, > 34, and > 41 ng/mL at < 1 hr post-CPB, 3 hr post-CPB, and 18–24 hr post-CPB, respectively; corrected NGAL > 422, > 125, and > 44 ng/mg creatinine at < 1 hr post-CPB, 3 hr post-CPB, and 18–24 hr post-CPB, respectively). S_Cr + defined according to study-specific creatinine-based definitions available at times comparable to urinary NGAL measurement (< 1 hr post-CPB and 3 hr post-CPB S_Cr+ defined as ΔS_Cr-initial ≥ 0.0 mg/dL; 18–24 hr post-CPB S_Cr+ defined as ΔS_{Cr-peak day 1} ≥ 0.2 mg/dL).

p < 0.05 when compared with c-statistic of multivariable base model without renal injury marker (0.86; 95% CI, 0.79–0.92).

S_Cr status defined by study-specific creatinine-based definitions available at times comparable to each urinary NGAL measurement.