Skip to main content
. 2020 Feb 11;25(9):745–e1265. doi: 10.1634/theoncologist.2020-0033
Number of Patients, Male 11
Number of Patients, Female 10
Stage Unresectable locally advanced or metastatic well‐differentiated G1 or 2 (Ki‐67 ≤20%)
Age Median (range): 57.4 (37.4–73.4)
Number of Prior Systemic Therapies Median (range): 3 (1.0–10.0)
Performance Status: ECOG

0 — 9

1 — 11

2 —

3 —

Unknown — 1

Other Patients eligible for enrollment were 18 years of age or older and had histologically or cytologically diagnosed, unresectable locally advanced, or metastatic well‐differentiated G1 or 2 pNET (Ki‐67 ≤20%), which had progressed on at least one line of prior systemic therapy. Patients previously treated with somatostatin analogs (SSAs), chemotherapy, antiangiogenics, mTOR inhibitors, radionuclides, or interferon were permitted providing that toxicity had resolved to grade ≤1 and 4 weeks had passed after last administration. Concomitant treatment with SSAs was allowed. Additionally, eligible patients had documented progression of disease by CT scan, magnetic resonance imaging, or somatostatin receptor scintigraphy within 12 months of study entry; ECOG performance status <2; and a life expectancy >12 weeks.
Cancer Types or Histologic Subtypes Pancreatic neuroendocrine