TABLE 3.
The univariate analysis of factors associated with PFS and OS in overall included patients.
| Variables | N | Progression-free survival |
Overall survival |
||||
| HR | 95% CI | P | HR | 95% CI | P | ||
| Age | 0.563 | 0.418 | |||||
| <50 year | 196 | 1 | 1 | ||||
| ≥50 year | 60 | 1.361 | 0.479–3.863 | 1.774 | 0.443–7.099 | ||
| BMI | 0.056 | 0.283 | |||||
| <24 kg/m2 | 164 | 1 | 1 | ||||
| ≥24 kg/m2 | 92 | 2.567 | 0.977–6.747 | 2.062 | 0.550–7.731 | ||
| Comorbidities | 0.196 | 0.019 | |||||
| 0 | 213 | 1 | 1 | ||||
| 1 | 34 | 1.005 | 0.227–4.456 | 1.177 | 0.141–9.805 | ||
| ≥2 | 9 | 3.904 | 0.878–17.361 | 10.438 | 2.013–54.113 | ||
| FIGO stage | 0.406 | 0.577 | |||||
| IA1 with LVSI + IA2 | 21 | 1 | 1 | ||||
| IB1 | 235 | 23.102 | 0.014–38018.254 | 22.675 | 3.9 × 10–4–1318638.17 | ||
| Histology | 0.830 | 0.689 | |||||
| SCC | 204 | 1 | 1 | ||||
| Non-SCC | 52 | 0.873 | 0.250–3.040 | 0.653 | 0.081–5.250 | ||
| Tumor grade | 0.900 | 0.705 | |||||
| G1 | 133 | 1 | 1 | ||||
| G2 | 66 | 1.297 | 0.424–3.967 | 1.790 | 0.357–8.983 | ||
| G3 | 57 | 1.133 | 0.341–3.767 | 1.846 | 0.367–9.286 | ||
| Adjuvant treatment | 0.224 | 0.137 | |||||
| No | 155 | 1 | 1 | ||||
| Yes | 101 | 1.807 | 0.697–4.684 | 2.879 | 0.715–11.593 | ||
| Positive resection margin | 0.858 | 0.896 | |||||
| No | 255 | 1 | 1 | ||||
| Yes | 1 | 0.049 | 2.7 × 10–12–9.1 × 1012 | 0.049 | 1.3 × 10–21–1.9 × 1018 | ||
| Parametrial involvement | 0.161 | 0.819 | |||||
| No | 250 | 1 | 1 | ||||
| Yes | 6 | 4.271 | 0.560–32.599 | 0.049 | 2.000–8.605 × 10–9 | ||
| Lymph node metastasis | 0.212 | 0.878 | |||||
| No | 232 | 1 | 1 | ||||
| Yes | 24 | 2.211 | 0.635–7.698 | 1.176 | 0.147–9.147 | ||
| Cervical stromal invasion depth | 0.144 | 0.489 | |||||
| <1/3 | 152 | 1 | 1 | ||||
| ≥1/3, <2/3 | 81 | 2.425 | 0.841–6.990 | 1.284 | 0.287–5.740 | ||
| ≥2/3 | 23 | 3.314 | 0.829–13.254 | 2.807 | 0.512–15.387 | ||
| Tumor mass size | 0.017 | 0.495 | |||||
| ≤2 cm | 175 | 1 | 1 | ||||
| >2 cm | 81 | 3.259 | 1.240–8.562 | 1.584 | 0.422–5.941 | ||
| Operation approach | 0.144 | 0.780 | |||||
| ARH | 84 | 1 | 1 | ||||
| LRH | 172 | 0.493 | 0.187–1.296 | 0.816 | 0.196–3.403 | ||
ARH, abdominal radical hysterectomy; LRH, laparoscopic radical hysterectomy; BMI, body mass index; FIGO, International Federation of Gynecology and Obstetrics; SCC, squamous-cell carcinoma.